läuft den der Ton? wie gesagt dann liegts wohl an den PlugINs. Hier ein Auszug aus der epsxe FAQ
Q: I keep getting some strange errors in the command line box in ePSXe...something
about MCI?
A: If you're having troubles with errors related to mci, or an empty black screen, upgrade
your ePSXe and use one of the internal CD-ROM plugins, depending on your OS. If you don't
wish to upgrade, or want to use another external plugin, then disable CDDA under Config
> Sound.
http://www.epsxe.com/files/ePSXe_FAQ.txt